Hydration-sensitive gene expression in brain.

Bad gene expression following effect of coenzyme Q10 on Wistar rat hippocampus with cerebral ischemia

Background: Q10 coenzyme is a potent antioxidant in the mitochondrial membrane. Releasing the oxygen free radicals occurs in the cerebral ischemia. Using Q10 coenzyme causes strength against oxidative after injury of cerebral ischemia during reperfusion. Also CoQ10 plays an important anti-apoptotic role to reduce Caspase 3 as a key enzyme neuroprotective in apoptosis. According to the sensitive...

Deep Brain Stimulation and Gene Expression Alterations in Parkinson’s Disease

Evaluation of acetylcholinesterase transcript level as a biomarker of methylmercury in orange spotted grouper (Epinephelus coioides) brain

The bioavailability of methylmercury (MeHg) in the brains of  orange spotted groupers, captured from four creeks of Mahshahr embayment was measured.  Then the effects of this pollutant on the regulation of gene expression, acetylcholinesterase transcript levels was chosen in order to monitor the amounts of methylmercury concentrations in the creeks, and the fluctuations of mRNA expressions in t...

THE EFFECT OF ENDURANCE TRAINING ON GENE EXPRESSION OF NERVE AND FIBROBLAST GROWTH FACTORS IN THE HIPPOCAMPUS OF RATS AFTER BRAIN STROKE

Background & Aims: Neurotrophic and growth factors are known to have positive effects on neuronal proliferation. However, findings on the effects of exercise training on these factors following brain stroke are limited. Thus, the aim of the present study was to investigate the effect of endurance training on gene expression of nerve growth factor (NGF) and fibroblast growth factor (FGF) in the ...

Effects of co-administration of ghrelin agonist (GHRP-2) and GH on TNF-α, IL-6 and iNOS gene expression induced by LPS in the mouse brain

The aim of this study was to examine the anti-inflammatory effects of co-administration of growthhormone-releasing peptide-2 (GHRP-2) and growth hormone (GH) on tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS) gene expression induced by LPS in the mousebrain. Thirty-five male NMRI mice (25±5 g) were injected through the mouse tail vein with saline,...

The effects of adenosine injection after of brain ischemia reperfusion injury on gene expression of NF-kB/p65 and activity level of ROS in male Wistar rats

Background: Unit of p65 is one of the subunits of NF-κB and its phosphorylation by stress oxidative causes activation of NF-κB. The aim of present study was to investigate the effects of adenosine injection after brain ischemia reperfusion injury on gene expression of NF-κB /p65 and Reactive Oxygen Species (ROS) in hippocampus tissue of male wistar rats. Methods: 40 male wistar rats were rando...